Boeing is to open an office in South Australia this month.

Boeing's new Adelaide office will support advanced military systems and leading edge research and development over the long term. The hub will work closely with universities, other tertiary institutions and research organisations.

Boeing's presence in Australia is already its largest outside of the United States, employing more than 3000 staff nationally, with the majority in Queensland.

However, it will be the first time it has had a presence in South Australia, which is positioning itself as the nation's "Defence State".

South Australian Premier Jay Weatherill said Boeing's decision to choose South Australia for its expansion demonstrated confidence in the state's future.

"Boeing's expansion in South Australia will create opportunities for highly-skilled workers in the defence and research sector, with flow on effects to the supply chain and broader economy. It also signals the increasing aerospace presence in South Australia," he said.

Adelaide is poised to become a global centre of excellence for the defence sector with more than AU$100 billion worth of major industry projects in the pipeline. Recent investment in innovation in South Australia includes an AU$230m Centre for Defence Industry Capability backed by the Australian Federal Government.